Establishing a “Ring‐Size‐Divergent” Synthetic Strategy: Synthesis, Structural Revision, and Absolute Configuration of Feroniellins

Feroniellin analogs isolated from Feroniella lucida possess a furanocoumarin skeleton connected to monoterpenic five- seven-membered ethereal rings by an ether linkage and exhibit broad spectrum of biological activities. In this contribution, we intended establish “ring-size-divergent” synthetic strategy for the through chemical sythesis feroniellins. The short comprehensive synthesis feroniellins was achieved in only two steps easily available bergamottin based on strategy. addition, these syntheses resulted revision proposed structures A B determination all absolute configurations feroniellins; their preliminary anti-inflammatory activities were investigated as well.